At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA, and base pairing to one of the two …

The interplay between telomere-associated proteins and telomerase, which sets the appropriate telomere length in different cellular stages and cell types, is an area that also requires rigorous …

While telomere shortening has been linked to the aging process, it is not yet known whether shorter telomeres are just a sign of aging like gray hair or actually contribute to aging.

2 days ago · A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a cell …

Aug 4, 2025 · The telomere’s role in aging becomes clear when you realize they’re not endlessly replenished. In most somatic (body) cells, telomeres shorten with every division, slowly ticking down …

Mar 30, 2025 · Telomere length varies between individual chromosomes, they do not have the same telomere length in all individuals. This can affect the measurement of telomeres.

Nov 20, 2025 · telomere, segment of DNA occurring at the ends of chromosomes in eukaryotic cells (cells containing a clearly defined nucleus). Telomeres are made up of repeated segments of DNA …

Jul 31, 2025 · During cell division, the DNA replication machinery cannot fully copy the very end of a chromosome, leading to a slight shortening of the telomere with each round of division.

Nov 29, 2024 · This Review discusses telomere maintenance and damage, and recent efforts to generate ‘humanized’-telomere mouse models.

Mar 22, 2023 · This chapter will present a high-level overview of the topics of human telomere structure and binding proteins, the role of telomeres in the DNA damage response and genome integrity, and …