Two new vasopressin antagonists, conivaptan and tolvaptan have recently been licensed for the treatment of hyponatremia in the USA. Their safety and clinical effectiveness seems promising, but high ...

May 27, 2009 (Silver Spring, Maryland) – The Food and Drug Administration has approved tolvaptan (Samsca, Otsuka America Pharmaceuticals), a selective vasopressin-receptor antagonist that can be taken ...

A consistent recent finding has been the strong association between hyponatremia and fractures. Initially, two case control studies reported the association of mild asymptomatic hyponatremia with bone ...

Potassium. If the patient is hypokalemic, administration of potassium will help increase the serum sodium concentration. Hourly IV “runs” of potassium chloride 10 mmol in 100 mL of normal saline, ...

Hyponatremia: An Update on the Management of SIADH Adding furosemide with or without sodium chloride to fluid restriction is not more effective than fluid restriction alone at correcting hyponatremia ...

New guidelines on the diagnosis, classification, and treatment of true hypotonic hyponatremia have been published online in the European Journal of Endocrinology. The guidelines focus on managing ...

People who have syndrome of inappropriate antidiuretic hormone secretion (SIADH) produce excessive amounts of antidiuretic hormones. It leads to the body developing an imbalance of sodium and water.

In older adults, low sodium often results from certain medications, kidney issues, or infections. Because multiple factors may contribute, treatment depends on identifying the underlying cause. Sodium ...